□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□ □□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □□□ □□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□ □□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□ □□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□Satoshi OBIKA 1）機能性人工核酸の合成研究ならびに基礎物性評価2）人工核酸の医薬応用に向けた研究3）核酸医薬の動態制御に向けた技術の開発4）核酸やタンパク質を題材とするケミカルバイオロジー研究教 授 講 師 講 師 助 教 特任准教授 特任助教（常勤） 小比賀 聡 Professor 山口 卓男 Senior Assistant Professor Takao YAMAGUCHI 06-6879-8201 樋野 展正 Senior Assistant Professor Nobumasa HINO 大澤 昂志 Assistant Professor Takashi OSAWA 永田 龍 Islam Md Ariful Specially Appointed Associate Professor Ryu NAGATA Specially Appointed Assistant Professor Md Ariful ISLAM 06-6879-8200 obika@phs.osaka-u.ac.jp06-6879-8176 hino@phs.osaka-u.ac.jp06-6879-4412 oosawa-t@phs.osaka-u.ac.jp06-6879-8203 nagata-r@phs.osaka-u.ac.jp06-6879-8202 yamaguchi-ta@phs.osaka-u.ac.jpariful-islam@phs.osaka-u.ac.jp教 授 小比賀 聡modifications on the duplex-forming ability. Chem. Eur. J., 2023, 29, e202301928.1. H. Kohashi, R. Nagata, Y. Tamenori, T. Amatani, Y. Ueda, Y. Mori, Y. Kasahara, S. Obika, M. Shimojo, A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic Acids Res., 2024, 52, 4784–4798.2. H. Togawa, T. Okubo, K. Horiuchi, T. Yamaguchi, E. Tomita-Sudo, T. Akita, J. Kawakami, S. Obika, Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions, J. Chromatogr. A, 2024, 1721, 464847.3. T. Osawa, T. Akino, S. Obika, Synthesis, duplex-forming ability, and enzymatic stability of oligonucleotides modified with amide-linked □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□J. Org. Chem., 2024, 89, 269–280.4. A. Mikami, S. Mori, T. Osawa, S. Obika, Post-synthetic nucleobase modification of DNA by Sonogashira coupling and influence of alkynyl 5. M. Hayashida，R. Suzuki, S. Horie, J. Masuda, T. Yamaguchi, S. Obika, Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study. J. Chromatogr. A, 2023, 1708, 464333.6. T. Yamaguchi, N. Horie, H. Aoyama, S. Kumagai, S. Obika, Mechanism of the extremely high duplex-forming ability of oligonucleotides modified □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□Nucleic Acids Res., 2023, 51, 7749–7761.7. K. Chiba, T. Yamaguchi, S. Obika, Development of 8–17 XNAzymes that are functional in cells. Chem. Sci., 2023, 14, 7620–7629.8. M. Yoshida, C. Oda, K. Mishima, I. Tsuji, S. Obika, M. Shimojo, An antisense amide-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells. Cancer Cell Int., 2023, 23, 8.9. Y. Sakurai, T. Yamaguchi, T. Yoshida, M. Horiba, T. Inoue, S. Obika, Synthesis and properties of nucleobase-sugar dual modified nucleic acids: 2-OMe-RNA and scpBNA bearing a 5-hydroxycytosine nucleobase. J. Org. Chem., 2023, 88, 154–162.10.R. Kita, T. Osawa, S. Obika, Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis. RSC. Chem. Biol., 2022, 3, 728–738.11.T. Yoshida, K. Morihiro, Y. Naito, A. Mikami, Y. Kasahara, T. Inoue, S. Obika, Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides, Nucleic Acids Res., 2022, 50, 7224–7234.□□□□□□□□ Bioorganic Chemistry
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