□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□ □□□□□□□□□□□□□□□□□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□ □□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□ □□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□教 授 准教授 助 教 助教（連合小児） 粟生 智香 Assistant Professor Tomoka Ao 橋本 均 Professor 永安 一樹 Associate Professor Kazuki Nagayasu 勢力 薫 Assistant Professor Kaoru SEIRIKI Hitoshi HASHIMOTO 06-6879-8180 hasimoto@phs.osaka-u.ac.jp06-6879-8183 nagayasu@phs.osaka-u.ac.jp06-6879-8182 06-6879-8182 Fax 06-6879-81841）脳・神経機能調節に関する分子薬理学的研究2）脳疾患の機構解明に向けた薬学的研究3）全脳細胞の形態および機能の定量的計測・解析技術の開発4）マルチスケールイメージング技術を用いた脳疾患の病態解明と創薬橋渡し研究seiriki@phs.osaka-u.ac.jpao-t@phs.osaka-u.ac.jp教 授 橋本 均1. Yokoyama R, et al. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Mol Psychiatry 2024; 29:1406-14162. Kojima L, et al. Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations. iScience 2024; 27:1098783. Agetsuma M, et al. Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation. Nat Commun , 2023; 14: 5996.4. Nagashima T, et al. Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice. Nat Commun, 2022; 13: 7913.5. Endo F, et al. Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science. 2022; 378:adc90206. Niu M, et al. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Sci Adv. 2022; 8:eabi6375 7. Matsumura K, et al. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nat Commun. 2020;11:859. 8. Seiriki K, et al. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. Nat Protoc. 2019;14:1509-1529.9. Seiriki K, et al. High-speed and scalable whole-brain imaging in rodents and primates. Neuron. 2017; 94:1085-1100.10. Nakazawa T, et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun. 2016; 7: 10594. □□□□□□□ Molecular Neuropharmacology
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