□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□１）ウイルス、細菌、がん細胞などの排除に関わる免疫応答の解明２）アレルギー疾患、自己免疫疾患、生活習慣病などの発症３）病原体やがん細胞の排除に働くワクチン、新たな抗炎症□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□493-504 (2022) A. 114, 2681-2686 (2017).immune responses. Adv Exp Med Biol. 997, 187-197 (2017).(2013). 1. Pan et al. Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation. Front Pharmacol. 14, 1250383 (2023) 2. Matsui et al. Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction. Int Immunol. 34, 505-518 (2022). □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ Int Immunol. 34, 4. Wang et al. Macrophage Response Driven by Extracellular ATP. Biol Pharm Bull. 44, 599-604 (2021). 5. Takahama et al. Autophagy limits activation of the inflammasomes. Immunol Rev. 281, 62-73 (2018). 6. Takahama et al. The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses. Cell Rep. 20, 2944-2954 (2017). 7. Kozaki et al. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc Natl Acad Sci U S 8. Misawa et al. Organelle Contact Sites: From Molecular Mechanism to Disease. Mitochondria-endoplasmic reticulum contact sites mediate innate 9. Saitoh & Akira. Regulation of inflammasomes by autophagy. J Allergy Clin Immunol. 138, 28-36 (2016). 10. Misawa et al. Resveratrol inhibits the acetylated a-tubulin-mediated assembly of the NLRP3-inflammasome. Int Immunol. 27, 425-434 (2015). 11. Misawa et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 14, 454-460 12. □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□Nature. 456, 264-268 (2008).Tatsuya SAITOH 06-6879-8170 06-6105-5793 Specially Appointed Assistant Professor Michihiro TAKAHAMA 06-6105-5793 教 授 齊藤 達哉 Professor 准教授 武村 直紀 Associate Professor Naoki TAKEMURA 特任助教 髙濵 充寛 に関わる誤った免疫応答の解明薬や抗アレルギー薬などの開発４）本分野のホームページも参照くださいhttp://saitohtatsuya.wixsite.com/saitohlabsaitohtatsuya@phs.osaka-u.ac.jptakemura-na@phs.osaka-u.ac.jptakahama-m@phs.osaka-u.ac.jp教 授 齊藤 達哉□□□□□□□□□Bioresponse Regulation
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