□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□ □□□□□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□教 授 澤間 善成 Professor 助 教 鹿又 喬平 Assistant Professor Yoshinari SAWAMA Kyohei KANOMATA 1) 生物活性化合物の合成2) 同位体置換法の開発と生命現象解明への応用3) 「重水素学」「重水素創薬」の開拓4) 相分離反応場の利用を鍵とする連続触媒反応の開発5) 創薬に資する精密機能分子合成06-6879-8210 06-6879-8213 sawama@phs.osaka-u.ac.jpkanomata@phs.osaka-u.ac.jp教 授 澤間 善成□□□□□□□□□□□□2023).1. Sawama, Y. et al., Photocatalytic and Chemoselective H/D Exchange at a-thio C(sp3)-H Bonds, J. Am. Chem. Soc□□□□□□□□□□□□□□□□□□□□□2025) 2. Sawama, Y. et al., Photocatalytic Multiple Deuteration of Polyethylene Glycol Derivatives Using Deuterium Oxide. Chem. Eur. J□□□□□□□□□□□□□□□2025).3 . S a w a m a , Y . e t a l . , C o n s t r u c t i o n o f F u n c t i o n a l i z e d o r t h o - N a p h t h o q u i n o n e M e t h i d e s v i a S i t e - S e l e c t i v e R i n g O p e n i n g o f 1-Siloxy-1,4-epoxy-1,4-dihydronaphthalenes, Adv. Synth. Catal., 365, 3981–3986 (2023).4. Sawama, Y. et al., Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Group in Drug Discovery. Angew. Chem. Int. Ed., □□□□□□□□□□□□2023).5. Sawama, Y. et al., Impact of Multiple H/D Replacement on the Physicochemical Properties of Flurbiprofen, RSC Med. Chem., 14, 2583–2592 (2023).6. Sawama, Y. et al., Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q, Chem. Commun., □□□□□□□□□□□□□□□□□2023)7. Sawama, Y. et al., Oxidative Two-way Regiocontrolled Coupling of 3-Methoxycarbonylcatechol and Indoles to Arylindoles, Chem. Commun., □□□□□□□□□□□□□□□□□□□□□□□2022).8. K. Kanomata et al, (S)-Convergent Deracemization of Racemic Esters with (R)-Selective Lipase: Pickering Emulsion Strategy for Enantiodivergent Synthesis using Native Enzyme, ACS Catal., 15, 6565–6571 (2025).9. K. Kanomata et al, Racemization of Chiral Sulfoxide using an Immobilized Oxovanadium Catalyst, Bull. Chem. Soc. J., 98, uoae144 (2025).□□□□K. Kanomata et al, Lipase/H2SO4-Cocatalyzed Dynamic Kinetic Resolution of Alcohols in Pickering Emulsion” , ChemCatChem, 15, □□□□□□□□ Organic and Medicinal Chemistry
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