□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□准教授（兼任） 06-6879-8235 辻野 博文 Associate Professor htsujino@phs.osaka-u.ac.jp1）グロビンタンパク質の構造と機能、及び活性酸素との関わり2）タンパク質工学に基づく機能改変タンパク質の創製3）薬物代謝酵素 CYP の薬物間相互作用や基質認識機構の解析4）各種分光分析法によるヘムタンパク質の酵素活性化機構の解明1. Derayea S. M. et al., Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates. Xenobiotica 50(12) 1510-1519, 2020 2. Mie Y. et al., Redox State Control of Human Cytoglobin by Direct Electrochemical Method to Investigate Its Function in Molecular Basis. Chem. Pharm. Bull, 68(8):806-809, 20203. Mie Y. et al., Nanoporous gold based electrodes for electrochemical studies of human neuroglobin. Electrochemistry Communications, 06621, 20204. Tsujino H. et al., Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity. Bioorg. Med. Chem. Lett., 29(19), 126607, 20195. Hanai S. et al., Roles of N- and C-terminal domains in the ligand-binding properties of cytoglobin. J. Inorg. Biochem., 179, 1-9, 20186. Ichikawa T. et al., Allosteric Activation of Cytochrome P450 3A4 by Efavirenz Facilitates Midazolam Binding. Xenobiotica, 18:1-10, 2017□□□□□□□□□□ Laboratory of enzymology
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