□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ Professor Associate Professor Assistant Professor Specially Appointed Professor Takeharu NAGAI Mitsuru HATTORI Chieko GOTO Jun-ichi MIYAZAKI １）蛍光および発光蛋白質を用いたセンサー開発２）発光センサーを利用した化合物スクリーニングシステムの開発３）オンサイト生理活性分子計測技術の開発06-6879-8480 06-6879-8481 06-6879-8481 06-6105-5934 永井 健治 教 授 服部 満 准教授 助 教 後藤千恵子 特任教授 宮崎 純一 ng1@sanken.osaka-u.ac.jp8tr@sanken.osaka-u.ac.jpgt0@sanken.osaka-u.ac.jpjimiyaza@nutri.med.osaka-u.ac.jp教 授 永井 健治図１ 化学発光プローブによるマウス個体を用いた分子活性評価の概念図 1. Fukushima S, Wazawa T, Sugiura K, Nagai T. Extremely sensitive genetically encoded temperature indicator enabling measurement at the 2. Tenma K et al. Selective plane activation structured illumination microscopy. Nature Methods, 21, 889-896, 2024 3. Lu Kai, Wazawa T, Matsuda T, Shcherbakova DM, Verkhusha VV, Nagai T. Near-infrared PAINT localization microscopy via chromophore replenishment of phytochrome-derived fluorescent tag. Communication Biology, 7, 243, 2024. 4. Agetsuma M et al. Activity-dependent organization of prefrontal hub-networks for associative leaning and signal transformation. Nature 5. Wazawa T, Nagai T. Joule heating involving ion currents through channel proteins. Biophysics and Physicobiology, 20, e200030, 2023 6. Sugiura K, Nagai T. Extension of the short wavelength side of fluorescent proteins using hydrated chromophores, and its application. 7. Lu K, Wazawa T, Sakamoto J, Vu CQ, Nakano M, Kamei Y, Nagai T. Intracellular heat transfer and thermal property revealed by kilohertz temperature imaging with a genetically encoded nanothermometer. Nano Letters, 22, 5698, 2022. 8. Goto A, Bota A, Miya K, Wang J, Tsukamoto S, Jiang X, Hirai D, Murayama M, Matsuda T, McHugh TJ, Nagai T, Hayashi Y. Stepwise synaptic 9. Hattori M, Sugiura N, Wazawa T, Matsuda T, Nagai T. Ratiometric bioluminescent indicator for a simple and rapid measurement of thrombin 10. Ichimura T, Kakizuka T, Horikawa K, Seiriki K, Kasai A, Hashimoto H, Fujita K, Watanabe TM, Nagai T. Exploring rare cellular activity in more than one million cells by a trans-scale scope. Scientific Reports, 11, 16539, 2021 organelle level. ACS Sensors, 9, 3889-3897, 2024. Communications, 14, 5996, 2023.Communications Biology, 5, 1172, 2022.plasticity events drive the early phase of memory consolidation. Science, 374, 857, 2021activity using a smartphone. Analytical Chemistry, 93, 13520, 2021図２ スマートフォンカメラ撮影による血中ビリルビン濃度計測法□□□□□□□□BiomolecularScience and Engineering
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