□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□Guest Professor 招へい教授 夏目やよい Yayoi NATSUME-KITATANI 06-6384-1574 natsume@nibiohn.go.jp1）オミックスデータや診療情報の解析を通して患者層別化や創薬標的探索、疾患発症機構の推論などを行う2）AI 創薬に資する新規アルゴリズムの開発を行う招へい教授 夏目やよい1. Akira Haga, Tae Iwasawa, Toshihiro Misumi, Koji Okudela, Tsuneyuki Oda, Hideya Kitamura, Tomoki Saka, Shoichiro Matsushita, Tomohisa Baba, Yayoi Natsume-Kitatani, Daisuke Utsunomiya, Takashi Ogura. Correlation of CT-based radiomics analysis with pathological cellular infiltration in fibrosing interstitial lung diseases. Japanese Journal of Radiology, 2024, 1-11.2. T.Enomoto, Y.Shirai, Y.Takeda, R.Edahiro, S.Shichino, M.Nakayama, M.Takahashi-Ihoh, Y.Noda, Y.Adachi, T.Kawasaki, T.Koba, Y.Futami, M.Yaga, Y.Hosono, H.Yoshimura, S.Amiya, R.Hara, M.Yamamoto, D.Nakatsubo, Y.Suga, M.Naito, K.Masuhiro, H.Hirata, K.Iwahori, I.Nagatomo, K.Miyake, S.Koyama, K.Fukushima, T.Shiroyama, Y.Naito, S.Futami, Y.Natsume-Kitatani, S.Nojima, M.Yanagawa, Y.Shintani, M.Nogami-Itoh, K.Mizuguchi, J.Adachi, T.Tomonaga, Y.Inoue, A.Kumanogoh. SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis, JCI Insight, 2024, 9(11)3. M.Tomoto, Y.Mineharu, N.Sato, Y.Tamada, M. Nogami-Itoh, M.Kuroda, J.Adachi, Y.Takeda, K. Mizuguchi, A.Kumanogoh, Y.Natsume Kitatani*, Y.Okuno. Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information, Scientific Reports, 2024, 14(1),13154. Y.Natsume-Kitatani, M.Nogami-Itoh, Y.Takeda, M.Kuroda, H.Hirata, K.Miyake, T.Shiroyama, Y.Shirai, Y.Noda, Y.Adachi, T.Enomoto, S.Amiya, J.Adachi, R.Narumi, S.Muraoka, T.Tomonaga, S.Kurohashi, F.Cheng, R.Tanaka, S.Yada, E.Aramaki, S.Wakamiya, Y.A.Chen, C.Higuchi, Y.Nojima, T.Fujiwara, C.Nagao, T.Takeda, Y.Matsumura, K.Mizuguchi, A.Kumanogoh, N.Ueda. Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients. preprint, 20235. H.Kawashima, R.Watanabe, T.Esaki, M.Kuroda, C.Nagao, Y.Natsume-Kitatani, R.Ohashi, H.Komura, K.Mizuguchi. DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis Platform, Journal of Medicinal Chemistry, 2023, 66(14), 9697-97096. S.Kozawa, K.Tejima, S.Takagi, M.Kuroda, M.Nogami Itoh, H.Kitamura, T.Niwa, T.Ogura, Y.Natsume Kitatani, T.N.Sato. Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach, Scientific Reports, 2023, 13(1),219817. M.G.Sohrab, K.N.A.Duong, G.Topi, M.Ikeda, N.Nagano, Y.Natsume-Kitatani, M.Kuroda, M.Nogami-Itoh, H.Takamura. Disease Network Constructor: a Pathway Extraction and Visualization, Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 3: System Demonstrations) , 2023, 549-5578. R.Watanabe, T.Kawata, S.Ueda, T.Shinbo, M.Higashimori, Y.Natsume-Kitatani, K.Mizuguchi. Prediction of the Contribution Ratio of a Target Metabolic Enzyme to Clearance from Chemical Structure Information, Molecular Pharmaceutics, 2023,20(1),419-4269. K.Hioki, T.Hayashi, Y.Natsume-Kitatani, K.Kobiyama, B.Temizoz, H.Negishi, H.Kawakami, H.Fuchino, E.Kuroda, C.Coban, N.Kawahara, K.J.Ishii. Machine-learning-assisted screening of herbal medicine extracts as vaccine adjuvants, Frontiers in Immunology, 2022,1310.□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□Literature, In Proceedings of the 2nd Conference of the Asia-Pacific Chapter of the Association for Computational Linguistics and the 12th International Joint Conference on Natural Language Processing: System Demonstrations, 2022, 63-7111.M.Otaki, N.Hirane, Y.Natsume-Kitatani, M.Nogami-Itoh, M.Shindo, Y.Kurebayashi, S.Nishimura. Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles, Scientific Reports, 2022, 12(1),17804 12.K.Hosomi, M.Saito, J.Park, H.Murakami, N.Shibata, M.Ando, T.Nagatake, K.Konishi, H.Ohno, K.Tanisawa, A.Mohsen, Y.Chen, H.Kawashima, Y.Natsume-Kitatani, Y.Oka, H.Shimizu, M.Furuta, Y.Tojima, K.Sawane, A.Saika, S.Kondo, Y.Yonejima, H.Takeyama, A.Matsutani, K.Mizuguchi, M.Miyachi, J.Kunisawa. Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota, Nature Communications, 2022, 13(1),4477□□□□□□□□ Computational Drug Discovery and Development
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