Research
Faculty Members
Biochemistry and Molecular Biology（Biology）
Inui TatsuyaSpecially Appointed Assistant Professor
By combining human iPS cell differentiation induction technology with organoid culture technology, we are developing highly functional human intestinal epithelial cells that can be applied to drug discovery research.
Research theme
Development of a highly functional human intestinal epithelial cell model for drug discovery
Orally administered drugs are first metabolized, absorbed, and excreted in the small intestine. Therefore, the development of safe drugs requires accurate prediction of drug kinetics in the intestinal tract. By combining human iPS cell differentiation induction technology with organoid culture technology, I am developing highly functional human intestinal epithelial cells for application in drug discovery research.
Representative achievements
Inui T., Uraya Y., Ueyama-Toba Y., Mizuguchi H. Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids. Eur. J. Cell Biol.104, 2 (2025)
Inui T., Uraya Y., Yokota J, Yamashita T, Kawai K, Okada K, Ueyama-Toba Y, Mizuguchi H. Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research. Stem Cell Res Ther 15, 57 (2024).
Inui T.#, Nomoto R.#, Yokota J., Yamashita T., Okada K., Kishimoto W., Nakase H., Mizuguchi H. Establishment of MDR1-knockout human enteroids for pharmaceutical application. #These authors contributed equally to this work. Drug Metab. Pharmacokinet. 48, 100476 (2023)
Inui T., Yamashita T., Tomita J., Yokota J., Kishimoto W., Nakase H., Mizuguchi H. Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual. Drug Metab. Pharmacokinet. 48, 100482 (2023).
