Graduate School and School of Pharmaceutical Sciences, The University of Osaka

Research

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Faculty Members

Drug Innovation Center Lead Exploration Unit

Komagawa ShinsukeSpecially Appointed Assosiate Professor / Lecturer

2009 Ph. D. (Science), Graduate School of Science, Tokyo University of Science
2009 Research Fellowship for Young Scientists, RIKEN
2010 Research Fellow, RIKEN
2011 Research Fellowship for Young Scientists, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2012 Visiting Researcher, ETH Zurich
2013 Assitant Professor, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
2016 Specially Appointed Assitant Professor, Graduate School of Pharmaceutical Sciences Drug Innovation Center, Osaka University
2025 Specially Appointed Researcher, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2026 Specially Appointed Assosiate Professor / Lecturer, Graduate School of Pharmaceutical Sciences Drug Innovation Center, The University of Osaka

Research theme

Promoting Drug Discovery Research by Lead Exploration

In order to develop academic seeds into potential pharmaceutical products, We support drug discovery research by utilizing the knowledge and skills accumulated in medicinal chemistry.

Reaction Development Integrating Experimental Chemistry, Theoretical Calculations, and Spectroscopy

We aim to create new possibilities through a cross-disciplinary, multifaceted approach. By combining experimental chemistry with spectroscopy —“chemistry that makes the invisible visible”— and computational chemistry —“chemistry that reveals what cannot be directly seen”— we seek to advance compound synthesis and develop novel reactions.

Representative achievements

Chiral Borinic Acid-Catalyzed Enantioselective Passerini-type Multicomponent Reaction
Kazuhiro Higashi, Shinsuke Komagawa, Yuta Chikashige, Tsunayoshi Takehara, Takeyuki Suzuki, Kenichi Murai, Mitsuhiro Arisawa, Makoto Sako
The Journal of Organic Chemistry 91(9), 2026, 3588-3593.

URL:https://doi.org/10.1021/acs.joc.5c03042

Construction of Functionalized ortho‐Naphthoquinone Methides via Site‐Selective Ring Opening of 1‐Siloxy‐1,4‐epoxy‐1,4‐dihydronaphthalenes
Takaaki Aijima, Shinsuke Komagawa, Shuji Akai, Yoshinari Sawama
Advanced Synthesis & Catalysis 365(22), 2023, 3981-3986.

URL:https://doi.org/10.1002/adsc.202300968

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin
Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun-Ichi Haruta, Seiji Takashima
Circulation 147(25), 2023, 1902-1918.

URL:https://doi.org/10.1161/CIRCULATIONAHA.122.062885

Experimental and Computational Investigation of Facial Selectivity Switching in Nickel–Diamine–Acetate-Catalyzed Michael Reactions
Yoshihiro Sohtome, Shinsuke Komagawa, Ayako Nakamura, Daisuke Hashizume, Sylvain Lectard, Mai Akakabe, Yoshitaka Hamashima, Masanobu Uchiyama, Mikiko Sodeoka
The Journal of Organic Chemistry, 88(22), 2023, 7764-7773.

URL:https://doi.org/10.1021/acs.joc.2c02732

Mechanistic origin of chemo-and regioselectivity of nickel-catalyzed [3 + 2 + 2] cyclization reaction
Shinsuke Komagawa, Chao Wang, Keiji Morokuma, Shinichi Saito, Masanobu Uchiyama
Journal of the American Chemical Society 135(39), 2013, 14508-14511.

URL:https://doi.org/10.1021/ja4068468

Amidocuprates for directed ortho cupration: Structural study, mechanistic investigation, and chemical requirements
Shinsuke Komagawa, Shinya Usui, Joanna Haywood, Philip J. Harford, Andrew E.H. Wheatley, Yotaro Matsumoto, Keiichi Hirano, Ryo Takita, Masanobu Uchiyama
Angewandte Chemie - International Edition 51(48), 2012, 12081-12085.

URL:https://doi.org/10.1002/anie.201204923

Synthesis of vinylcycloheptadienes by the nickel-catalyzed three-component [3 + 2 + 2] cocyclization. Application to the synthesis of polycyclic compounds
Shinsuke Komagawa, Kouhei Takeuchi, Ikuo Sotome, Isao Azumaya, Hyuma Masu, Ryu Yamasaki, Shinichi Saito
Journal of Organic Chemistry 74(9), 2009, 3323-3329.

URL:https://doi.org/10.1021/jo900189g

Nickel-catalyzed three-component [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes - Selective synthesis of multisubstituted cycloheptadienes
Shinsuke Komagawa, Shinichi Saito
Angewandte Chemie - International Edition 45(15), 2006, 2446-2449

URL:https://doi.org/10.1002/anie.200504050

Nickel-catalyzed intermolecular [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate and alkynes
Shinichi Saito, Manami Masuda, Shinsuke Komagawa
Journal of the American Chemical Society 126(34), 2004, 10540-10541.

URL:https://doi.org/10.1021/ja0494306

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