Graduate School and School of Pharmaceutical Sciences, The University of Osaka

Research

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Faculty Members

Organic and Medicinal Chemistry（Chemistry）

Hashimoto RiichiAssistant professor

Graduated from the Faculty of Pharmacy, Department of Pharmaceutical Sciences, Keio University in 2018. Completed the Master’s Program (First-Term Doctoral Program) at the Graduate School of Pharmaceutical Sciences, Keio University in 2020. Completed the Doctoral Program (Ph.D. in Pharmaceutical Sciences) at the same graduate school in 2023. Served as a Special Postdoctoral Researcher at RIKEN in 2023. Has held the current position since April 2026.

Research theme

Reaction development that enables the synthesis of biologically active compounds

We aim to develop reactions that facilitate the synthesis of pharmaceuticals and biologically active compounds with potential as drug candidates. In particular, we focus on reactions that enable the modification of aromatic rings and precise control of reaction sites, and we are also engaged in the derivatization of biologically active molecules.

Reaction development toward chemical biology

We aim to develop reactions that contribute to the elucidation of biological phenomena. We also work on the design of new functions and the evaluation of their performance.

Representative achievements

Unified short syntheses of oxygenated tricyclic aromatic diterpenes by radical cyclization with a photoredox catalyst . R. R. Hashimoto*, K. Hanaya, T. Sugai, S. Higashibayashi* Commun. Chem. 2023, 6, 169.

URL:https://www.nature.com/articles/s42004-023-00979-2

1,2-Rearrangement fromo-Quinols to Multisubstituted Catechols via Retro Diels-Alder Reaction ortho-Quinol Dimers . R. Hashimoto, K. Hanaya, T. Sugai, S. Higashibayashi* Bull. Chem. Soc. Jpn. 2022, 95, 663.

URL:https://academic.oup.com/bcsj/article/95/4/663/7257745

Chemoenzymatic semisynthesis of caffeic acid β-phenethyl ester, an antioxidative component in propolis, from raw coffee bean extract. R. Hashimoto, H. Iai, R. Fujita, K. Hanaya, S. Higashibayashi, H. Inoue, T. Sugai* Biosci. Biotechnol. Biochem. 2020, 85, 476.

URL:https://academic.oup.com/bbb/article/85/3/476/6056120

Lipase-Catalyzed Site-Selective Deacetylation of Sterically Hindered Naphthohydroquinone Diacetate and Its Application to the Synthesis of a Heterocyclic Natural Product. R. Hashimoto, A. Sakakura, K. Hanaya, S. Higashibayashi, T. Sugai* Heterocycles 2019, 99, 625.

URL:https://triggered.stanford.clockss.org/ServeContent?doi=10.3987%2Fcom-18-s%28f%2912

Utilization　of　Lipase-Catalyzed　Acetylationand Deacetylation　in the　Synthesis　of　a　Natural　Product　with　a Hydroquinone　Skeleton. T. Sugai*, K. Honda, R. Hashimoto, K. Hanaya, S. Higashibayashi Asian J. Org. Chem. 2024, e202400303.

URL:https://aces.onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202400303

Synthesis of phenanthridine derivatives by a water-compatible gold-catalyzed hydroamination. Y. Lin, R. Hashimoto, T.-C. Chang, K. Tanaka* Bioorg. Med. Chem. 2024, 113, 117928.

URL:https://www.sciencedirect.com/science/article/pii/S0968089624003420

Comprehensive semisyntheses of catathelasmols C, D, and E from D-glutamic acid, utilizing lipase-catalyzed site-selective reactions on intermediates. R. Hashiba, R. Hashimoto, M. Nishiguchi, T. Kobayashi, K. Hanaya, S. Higashibayashi, T. Sugai* Biosci. Biotechnol. Biochem. 2020, 84, 1339.

URL:https://academic.oup.com/bbb/article/84/7/1339/5937560

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